COURSE MOD

COURSE MODIFICATION

Originator Max Funk, x1509, mfunk@uoft02.utoledo.edu

Department CHEMISTRY

PRESENT PROPOSED

6/8300 Advanced Analytical Chemistry

6/8310 Separation Methods

6/8320 Characterization of Condensed Phases and Surfaces Electrochemistry

6/8330 Spectroscopic Methods and Analysis of Spectra

6/8400 Advanced Organic Chemistry

6/8410 Organic Synthesis

6/8420 Physical Organic Chemistry & Reaction Mechanisms

6/8500 Advanced Biological Chemistry

6/8510 Protein Chemistry

6/8520 Enzymology

6/8530 Nucleic Acid Chemistry

6/8600 Advanced Inorganic and Organometallic Chemistry Physical Inorganic Chemistry

6/8610 Inorganic and Organometallic Chemistry of Transition and Post-Transition Elements Chemistry of Transition and Post-Transition Elements

6/8700 Advanced Physical Chemistry

6/8710 Molecular Structure and Dynamics

6/8850 X-Ray Crystallography

Hours 2-4 4 (6310: 3)

Grading

Pre-/Co-requisites

Catalog Description 6/8300 New techniques in characterization/compositional analysis of materials in the condensed state, i.e., organic, polymeric, inorganic and composites. Section 2 (2 hours): Principles of techniques described. Includes surface characterization, rheology and electrochemical properties. Section 3 (4 hours): Material covered in Section 1 and 2. Prerequisite: Permission of department. An overview of new techniques in analytical chemistry. Topics include sample preparation and sampling, spectroscopic, separation, electrochemical, surface characterization and thermal methods.

6/8310 The theory and design of separation methods. Section 2 (2 hours): Application of separation methods. Section 3 (4 hours): Material covered in Section 1 and 2. Topics include extraction techniques, gas, liquid, and supercritical fluid chromatography, affinity and chiral separation, and capillary electrophoresis. Approved chemical safety goggles meeting the American national Standard 287.1-1968 must be worn by every student during every laboratory class meeting. Prerequisite: Permission of department The theory, design and application of separation methods. Topics include extraction techniques, gas, liquid, and supercritical fluid chromatography, affinity and chiral separation, and capillary electrophoresis.

6/8320 Modular study of the theory, instrumentation and methods of analysis for the characterization and analysis of liquid, solution and solid phases. Section 1 (2 hours): A fundamental study of electrochemical concepts, methods, instrumentation and applications. Section 2 (2 hours): A study of surface analysis and colloid and interfacial chemistry. Section 3 (4 hours): Material covered in Section 1 and 2. Prerequisite: Permission of department. A fundamental study of electrochemical concepts, methods, instrumentation and applications.

6/8330 Section 1 (2 hours): A comprehensive study of theory and instrumentation. Section 2 (2 hours): Applications of spectrorscopic methods including spectral interpretation. Section 3 (4 hours): Materials covered in Sections 1 and 2. Topics include a study of absorption, emission, Raman, NMR, ESR, mass spectrometry, and related subjects. A comprehensive study of theory and instrumentation. Applications of spectrorscopic methods including spectral interpretation. Topics include a study of absorption, emission, Raman, NMR, ESR, mass spectrometry, and related subjects. Important methodology and strategy in organic synthesis including disconnection and retrosynthetic analysis.

6/8400 Section 1 (2 hours): Basic heterocyclic synthesis and methodology. Section 2 (2 hours): Reducing reagents and new carbon-carbon forming processes. Section 3 (4 hours): materials covered in Sections 1 and 2. Physical basis of organic chemistry. Molecular orbital theory, organic reaction mechanisms and reactive intermediates.

6/8410 Section 1 (2 hours): Important methodology in organic synthesis. Section 2 (2 hours): Disconnection and retroanalysis. Section 3 (4 hours): Materials covered in Sections 1 and 2. Important methodology and strategy in organic synthesis including disconnection and retrosynthetic analysis.

6/8420 Section 1 (2 hours): Physical basis of organic chemistry. Section 2 (2 hours): Molecular orbital theory, mechanistic chemistry and reactive intermediates. Section 3 (4 hours): materials covered in Sections 1 and 2. Advanced and current topics related to organic chemistry, for example: bioorganic chemistry and chemical biology.

6/8500 The chemistry of cellular and molecular transformations in biochemical systems. Section 1 (2 hours): Molecular structure of proteins, nucleic acids, and membranes. Section 2 (2 hours): Metabolism and biosynthesis of carbohydrates, amino acids and lipids; gene regulation and replication. Section 3 (4 hours): Materials covered in Sections 1 and 2. The chemistry of cellular and molecular transformations in biochemical systems. Molecular structure of proteins, nucleic acids, and membranes. Metabolism and biosynthesis of carbohydrates, amino acids and lipids; gene regulation and replication.

6/8510 Section 1 (2 hours): A detailed analysis of the structure and function of proteins. Section 2 (2 hours): Current methodology for the analysis of structure, the basis for molecular associations, and relationships between structure and function. Section 3 (4 hours): Materials covered in Sections 1 and 2. A detailed analysis of the structure and function of proteins. Current methodology for the analysis of protein structure, the basis for molecular associations, and relationships between structure and function.

6/8520 The principles of chemical catalysis applied to molecular enzymology. Section 1 (2 hours): Catalysis: kinetics, steady state vs. numerical integration, the proton nin chemistry, coenzymes, metal ions, enzyme mechanism, allosterism, conformational effects. Section 2 (2 hours): Methodology: site-directed mutagenesis, affinity labeling, monoclonal and antipeptide antibodies, isotope effects, catalytic antibodies. Section 3 (4 hours): Materials covered in Sections 1 and 2. Survey of current methods to study enzyme-catalyzed reactions, and application to examples from major enzyme groups. Current topics in enzymology include abzymes and ribozymes, artificial enzymes, and enzyme engineering.

6/8530 The chemical basis for the storage and transmission of genetic information. Section 1 (2 hours): Nucleic acid structure, DNA/RNA: sequence and conformational analysis, 3D solution and solid state structures, complexes, proteins, ribosomes, nucleosomes, networks, chromosomes. Section 2 (2 hours): Biological Consequences: mutagenesis, carcinogenesis, chemotherapeutic strategies; properties and chemistry: hybridization and higher order complexes, interactions with small molecules, cleavage reactions, mismatch, damage, repair. Section 3 (4 hours): Materials covered in Sections 1 and 2. The structural and chemical properties of nucleic acids and the resulting biological consequences. Topics include: 3D structures, conformation, protein/nucleic acid interactions, physical properties and chemical reactions, mutagenesis, damage/repair, and recombination.

6/8600 The inorganic chemistry of the main group elements, transition metals, lanthanides and actinides is described. Section 2 (2 hours): Bonding, structure and reactivity are considered and appropriate concepts applied. Section 3: (4 hours) Material covered in Sections 1 and 2. Symmetry, bonding theories, magnetism, and spectroscopic characterization of inorganic compounds are described. Coverage of spectroscopic techniques such as NMR, EPR, UV/VIS, IR, and Mossbauer focus on applications to inorganic systems.

6/8610 Section 1 (2 hours): The inorganic and organometallic chemistry of the transition metals, lanthanides and actinides is described. Bonding, structure and reactivity are considered. Section 2 (2 hours): Applications in areas such as bioinorganic chemistry, catalytic synthesis and materials chemistry are discussed. Section 3 (4 hours): Material covered in Sections 1 and 2. The inorganic and organometallic chemistry of the transition metals, lanthanides, and actinides is described. Synthesis, structure, bonding, and reactivity are considered. Applications in catalysis, bioinorganic, and materials chemistry are discussed.

6/8700 Section 1 (2 hours): Classical chemical thermodynamics and kinetic rate laws and mechanisms. Section 2 (2 hours): Energetic considerations in electrochemistry. Section 3 (4 hours): Material covered in Sections 1 and 2. Chemical systems and processes in the context of classical equilibrium thermodynamics. It introduces non-equilibrium and statistical thermodynamics to elucidate chemical changes and the connection between molecular and macroscopic system properties.

6/8710 Section 1 (2 hours): Introduction to electronic structures of molecules. Section 2 (2 hours): Chemical dynamics and statistical mechanics. Section 3 (4 hours): Material covered in Sections 1 and 2. Fundamental principles of quantum mechanics and their application to model systems, atoms and molecules; Introduction to molecular spectroscopy.

6/8850 Theory and practice of molecular structure determination by X-ray diffraction. Section 1 (2 hours): Small molecule crystallography. Section 2 (2 hours): Macromolecular crystallography. Section 3: (4 hours) Material in Sections 1 and 2. Theory and practice of structure determination by X-ray diffraction. Basics of symmetry, diffraction, and reciprocal space. Hands-on introduction to single-crystal and powder methods.

Reason for Change Update catalog description; fix credit hours at 4; remove modular format.
CHEM6400/8400 as currently being taught covers the course content previously described for CHEM6420/8420. CHEM6420/8420 will be modified in order to expose students to a wider array of chemistry topics. The change of credit hours will more accurately reflect the workload.

Content Changed? Yes; variable

COURSE MODIFICATION
Originator	Max Funk, x1509, mfunk@uoft02.utoledo.edu
Department	CHEMISTRY
	PRESENT	PROPOSED
6/8300	Advanced Analytical Chemistry
6/8310	Separation Methods
6/8320	Characterization of Condensed Phases and Surfaces	Electrochemistry
6/8330	Spectroscopic Methods and Analysis of Spectra
6/8400	Advanced Organic Chemistry
6/8410	Organic Synthesis
6/8420	Physical Organic Chemistry & Reaction Mechanisms
6/8500	Advanced Biological Chemistry
6/8510	Protein Chemistry
6/8520	Enzymology
6/8530	Nucleic Acid Chemistry
6/8600	Advanced Inorganic and Organometallic Chemistry	Physical Inorganic Chemistry
6/8610	Inorganic and Organometallic Chemistry of Transition and Post-Transition Elements	Chemistry of Transition and Post-Transition Elements
6/8700	Advanced Physical Chemistry
6/8710	Molecular Structure and Dynamics
6/8850	X-Ray Crystallography
Hours	2-4	4 (6310: 3)
Grading
Pre-/Co-requisites
Catalog Description 6/8300	New techniques in characterization/compositional analysis of materials in the condensed state, i.e., organic, polymeric, inorganic and composites. Section 2 (2 hours): Principles of techniques described. Includes surface characterization, rheology and electrochemical properties. Section 3 (4 hours): Material covered in Section 1 and 2. Prerequisite: Permission of department.	An overview of new techniques in analytical chemistry. Topics include sample preparation and sampling, spectroscopic, separation, electrochemical, surface characterization and thermal methods.
6/8310	The theory and design of separation methods. Section 2 (2 hours): Application of separation methods. Section 3 (4 hours): Material covered in Section 1 and 2. Topics include extraction techniques, gas, liquid, and supercritical fluid chromatography, affinity and chiral separation, and capillary electrophoresis. Approved chemical safety goggles meeting the American national Standard 287.1-1968 must be worn by every student during every laboratory class meeting. Prerequisite: Permission of department	The theory, design and application of separation methods. Topics include extraction techniques, gas, liquid, and supercritical fluid chromatography, affinity and chiral separation, and capillary electrophoresis.
6/8320	Modular study of the theory, instrumentation and methods of analysis for the characterization and analysis of liquid, solution and solid phases. Section 1 (2 hours): A fundamental study of electrochemical concepts, methods, instrumentation and applications. Section 2 (2 hours): A study of surface analysis and colloid and interfacial chemistry. Section 3 (4 hours): Material covered in Section 1 and 2. Prerequisite: Permission of department.	A fundamental study of electrochemical concepts, methods, instrumentation and applications.
6/8330	Section 1 (2 hours): A comprehensive study of theory and instrumentation. Section 2 (2 hours): Applications of spectrorscopic methods including spectral interpretation. Section 3 (4 hours): Materials covered in Sections 1 and 2. Topics include a study of absorption, emission, Raman, NMR, ESR, mass spectrometry, and related subjects.	A comprehensive study of theory and instrumentation. Applications of spectrorscopic methods including spectral interpretation. Topics include a study of absorption, emission, Raman, NMR, ESR, mass spectrometry, and related subjects. Important methodology and strategy in organic synthesis including disconnection and retrosynthetic analysis.
6/8400	Section 1 (2 hours): Basic heterocyclic synthesis and methodology. Section 2 (2 hours): Reducing reagents and new carbon-carbon forming processes. Section 3 (4 hours): materials covered in Sections 1 and 2.	Physical basis of organic chemistry. Molecular orbital theory, organic reaction mechanisms and reactive intermediates.
6/8410	Section 1 (2 hours): Important methodology in organic synthesis. Section 2 (2 hours): Disconnection and retroanalysis. Section 3 (4 hours): Materials covered in Sections 1 and 2.	Important methodology and strategy in organic synthesis including disconnection and retrosynthetic analysis.
6/8420	Section 1 (2 hours): Physical basis of organic chemistry. Section 2 (2 hours): Molecular orbital theory, mechanistic chemistry and reactive intermediates. Section 3 (4 hours): materials covered in Sections 1 and 2.	Advanced and current topics related to organic chemistry, for example: bioorganic chemistry and chemical biology.
6/8500	The chemistry of cellular and molecular transformations in biochemical systems. Section 1 (2 hours): Molecular structure of proteins, nucleic acids, and membranes. Section 2 (2 hours): Metabolism and biosynthesis of carbohydrates, amino acids and lipids; gene regulation and replication. Section 3 (4 hours): Materials covered in Sections 1 and 2.	The chemistry of cellular and molecular transformations in biochemical systems. Molecular structure of proteins, nucleic acids, and membranes. Metabolism and biosynthesis of carbohydrates, amino acids and lipids; gene regulation and replication.
6/8510	Section 1 (2 hours): A detailed analysis of the structure and function of proteins. Section 2 (2 hours): Current methodology for the analysis of structure, the basis for molecular associations, and relationships between structure and function. Section 3 (4 hours): Materials covered in Sections 1 and 2.	A detailed analysis of the structure and function of proteins. Current methodology for the analysis of protein structure, the basis for molecular associations, and relationships between structure and function.
6/8520	The principles of chemical catalysis applied to molecular enzymology. Section 1 (2 hours): Catalysis: kinetics, steady state vs. numerical integration, the proton nin chemistry, coenzymes, metal ions, enzyme mechanism, allosterism, conformational effects. Section 2 (2 hours): Methodology: site-directed mutagenesis, affinity labeling, monoclonal and antipeptide antibodies, isotope effects, catalytic antibodies. Section 3 (4 hours): Materials covered in Sections 1 and 2.	Survey of current methods to study enzyme-catalyzed reactions, and application to examples from major enzyme groups. Current topics in enzymology include abzymes and ribozymes, artificial enzymes, and enzyme engineering.
6/8530	The chemical basis for the storage and transmission of genetic information. Section 1 (2 hours): Nucleic acid structure, DNA/RNA: sequence and conformational analysis, 3D solution and solid state structures, complexes, proteins, ribosomes, nucleosomes, networks, chromosomes. Section 2 (2 hours): Biological Consequences: mutagenesis, carcinogenesis, chemotherapeutic strategies; properties and chemistry: hybridization and higher order complexes, interactions with small molecules, cleavage reactions, mismatch, damage, repair. Section 3 (4 hours): Materials covered in Sections 1 and 2.	The structural and chemical properties of nucleic acids and the resulting biological consequences. Topics include: 3D structures, conformation, protein/nucleic acid interactions, physical properties and chemical reactions, mutagenesis, damage/repair, and recombination.
6/8600	The inorganic chemistry of the main group elements, transition metals, lanthanides and actinides is described. Section 2 (2 hours): Bonding, structure and reactivity are considered and appropriate concepts applied. Section 3: (4 hours) Material covered in Sections 1 and 2.	Symmetry, bonding theories, magnetism, and spectroscopic characterization of inorganic compounds are described. Coverage of spectroscopic techniques such as NMR, EPR, UV/VIS, IR, and Mossbauer focus on applications to inorganic systems.
6/8610	Section 1 (2 hours): The inorganic and organometallic chemistry of the transition metals, lanthanides and actinides is described. Bonding, structure and reactivity are considered. Section 2 (2 hours): Applications in areas such as bioinorganic chemistry, catalytic synthesis and materials chemistry are discussed. Section 3 (4 hours): Material covered in Sections 1 and 2.	The inorganic and organometallic chemistry of the transition metals, lanthanides, and actinides is described. Synthesis, structure, bonding, and reactivity are considered. Applications in catalysis, bioinorganic, and materials chemistry are discussed.
6/8700	Section 1 (2 hours): Classical chemical thermodynamics and kinetic rate laws and mechanisms. Section 2 (2 hours): Energetic considerations in electrochemistry. Section 3 (4 hours): Material covered in Sections 1 and 2.	Chemical systems and processes in the context of classical equilibrium thermodynamics. It introduces non-equilibrium and statistical thermodynamics to elucidate chemical changes and the connection between molecular and macroscopic system properties.
6/8710	Section 1 (2 hours): Introduction to electronic structures of molecules. Section 2 (2 hours): Chemical dynamics and statistical mechanics. Section 3 (4 hours): Material covered in Sections 1 and 2.	Fundamental principles of quantum mechanics and their application to model systems, atoms and molecules; Introduction to molecular spectroscopy.
6/8850	Theory and practice of molecular structure determination by X-ray diffraction. Section 1 (2 hours): Small molecule crystallography. Section 2 (2 hours): Macromolecular crystallography. Section 3: (4 hours) Material in Sections 1 and 2.	Theory and practice of structure determination by X-ray diffraction. Basics of symmetry, diffraction, and reciprocal space. Hands-on introduction to single-crystal and powder methods.
Reason for Change	Update catalog description; fix credit hours at 4; remove modular format. CHEM6400/8400 as currently being taught covers the course content previously described for CHEM6420/8420. CHEM6420/8420 will be modified in order to expose students to a wider array of chemistry topics. The change of credit hours will more accurately reflect the workload.
Content Changed?	Yes; variable